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Rizk, N., Aly, S., Khidr, M. (2022). Synthesis, characterization, DNA binding of nano Mn2+and Cu2+complexes. Research Journal of Applied Biotechnology, 8(1), 11-26. doi: 10.21608/rjab.2022.292262
Nashwa Mokhtar Hassan Rizk; Samar A. Aly; Manal A. Khidr. "Synthesis, characterization, DNA binding of nano Mn2+and Cu2+complexes". Research Journal of Applied Biotechnology, 8, 1, 2022, 11-26. doi: 10.21608/rjab.2022.292262
Rizk, N., Aly, S., Khidr, M. (2022). 'Synthesis, characterization, DNA binding of nano Mn2+and Cu2+complexes', Research Journal of Applied Biotechnology, 8(1), pp. 11-26. doi: 10.21608/rjab.2022.292262
Rizk, N., Aly, S., Khidr, M. Synthesis, characterization, DNA binding of nano Mn2+and Cu2+complexes. Research Journal of Applied Biotechnology, 2022; 8(1): 11-26. doi: 10.21608/rjab.2022.292262

Synthesis, characterization, DNA binding of nano Mn2+and Cu2+complexes

Article 2, Volume 8, Issue 1, June 2022, Page 11-26  XML PDF (668.21 K)
Document Type: Original Article
DOI: 10.21608/rjab.2022.292262
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Authors
Nashwa Mokhtar Hassan Rizkorcid ; Samar A. Aly email ; Manal A. Khidr
Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City 32958, Egypt.
Abstract
New complexes for Mn2+ and Cu2+ were prepared and characterized from ligand, 2-(phenylglycyl)-N-(p-tolyl)hydrazine-1-carbo thioamide (H2L) and binuclear Cu2+ complex (B3) of hydrazone derivatives . The structural compositions of the novel chelates were clarified using spectral, molar conductivity, FTIR, UV-Visible spectra,TGA, XRD and analytical techniques. The outcomes supported the ligand's neutral bidentate or monobasic tridentate behaviour. Coordination bonding has occurred via carbonyl oxygen (C=O) and N(2)H or (C-S) groups in complex (B1). The synthesized mononuclear complexes B1and B2 displayed an octahedral  , square  planar form . While B3 complex is binuclear . Also, the Cu2+complex (B2) has a stronger antibacterial and anticancer activity than the Mn2+complex and the ligand when tested against different bacterial species and the HepG2 cell line. Respectively; The binding ability of ligand and Cu2+ complex (B2) with CT-DNA was aimed  to for being intercelation or alternative strategy. The constant of  intrinsic binding Kb was estimated .
Keywords
Complexes; DNA binding; Infrared; TGA; Antibacterial
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