Genetic evaluation of CD28 rs3116496 in Egyptian children with Type 1 Diabetes (T1D)

Document Type : Original Article

Authors

1 Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

2 Pediatric Department, Faculty of Medicine, Tanta University, Egypt.

3 Department of Bioinformatics, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Abstract

The genetic contribution of Cluster of Differentiation 28 (CD28) toward type 1 diabetes (T1D) was investigated in several ethnic groups.The genotyping of CD28 rs3116496 (+17 T/C) polymorphism was performed in the Egyptian population (101 T1D patients and 100 healthy controls) by using a single-stranded-polymorphism-PCR (SSP-PCR). Despite the comparable genetic distribution of CD28 between the two groups, patients had significantly higher CT/TT against CC than healthy individuals (P<0.05 and OR=3.63). Sodium levels were decreased in patients with the CC genotype (CD28 C/T), whereas urea levels were raised in TT genotype patients. Our present study found that there may be a link between Egyptian children's T1D risk and CD28 variants.

Keywords

Files

Share

How to cite

Statistics