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Ali, Y., Elkera, D., Elakhras, B., El-Mahdy, H., Osman, M. (2022). Genetic evaluation of CD28 rs3116496 in Egyptian children with Type 1 Diabetes (T1D). Research Journal of Applied Biotechnology, 8(1), 27-34. doi: 10.21608/rjab.2022.357079
Yasser B.M. Ali; Dina R. Elkera; Basima A. Elakhras; Heba S. El-Mahdy; Mohamed Osman. "Genetic evaluation of CD28 rs3116496 in Egyptian children with Type 1 Diabetes (T1D)". Research Journal of Applied Biotechnology, 8, 1, 2022, 27-34. doi: 10.21608/rjab.2022.357079
Ali, Y., Elkera, D., Elakhras, B., El-Mahdy, H., Osman, M. (2022). 'Genetic evaluation of CD28 rs3116496 in Egyptian children with Type 1 Diabetes (T1D)', Research Journal of Applied Biotechnology, 8(1), pp. 27-34. doi: 10.21608/rjab.2022.357079
Ali, Y., Elkera, D., Elakhras, B., El-Mahdy, H., Osman, M. Genetic evaluation of CD28 rs3116496 in Egyptian children with Type 1 Diabetes (T1D). Research Journal of Applied Biotechnology, 2022; 8(1): 27-34. doi: 10.21608/rjab.2022.357079

Genetic evaluation of CD28 rs3116496 in Egyptian children with Type 1 Diabetes (T1D)

Article 3, Volume 8, Issue 1, June 2022, Page 27-34  XML PDF (272.38 K)
Document Type: Original Article
DOI: 10.21608/rjab.2022.357079
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Authors
Yasser B.M. Ali email 1; Dina R. Elkera2; Basima A. Elakhras1; Heba S. El-Mahdy2; Mohamed Osman3
1Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.
2Pediatric Department, Faculty of Medicine, Tanta University, Egypt.
3Department of Bioinformatics, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.
Abstract
The genetic contribution of Cluster of Differentiation 28 (CD28) toward type 1 diabetes (T1D) was investigated in several ethnic groups.The genotyping of CD28 rs3116496 (+17 T/C) polymorphism was performed in the Egyptian population (101 T1D patients and 100 healthy controls) by using a single-stranded-polymorphism-PCR (SSP-PCR). Despite the comparable genetic distribution of CD28 between the two groups, patients had significantly higher CT/TT against CC than healthy individuals (P<0.05 and OR=3.63). Sodium levels were decreased in patients with the CC genotype (CD28 C/T), whereas urea levels were raised in TT genotype patients. Our present study found that there may be a link between Egyptian children's T1D risk and CD28 variants.
Keywords
Keywords: Diabetic; Single nucleotide polymorphisms; PCR; CD28
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