Aly, S., Hassan, S., Farfour, S., Abdalla, E., Abdel-hady, T. (2024). Synthesis, characterization and biological activity of cadmium (II) complex of hydrazone moiety. Research Journal of Applied Biotechnology, 10(2), 12-23. doi: 10.21608/rjab.2024.312873.1055
Samar A. Aly; Safaa Hassan; Safinaz A. Farfour; Ehab M. Abdalla; Tasneem Abdel-hady. "Synthesis, characterization and biological activity of cadmium (II) complex of hydrazone moiety". Research Journal of Applied Biotechnology, 10, 2, 2024, 12-23. doi: 10.21608/rjab.2024.312873.1055
Aly, S., Hassan, S., Farfour, S., Abdalla, E., Abdel-hady, T. (2024). 'Synthesis, characterization and biological activity of cadmium (II) complex of hydrazone moiety', Research Journal of Applied Biotechnology, 10(2), pp. 12-23. doi: 10.21608/rjab.2024.312873.1055
Aly, S., Hassan, S., Farfour, S., Abdalla, E., Abdel-hady, T. Synthesis, characterization and biological activity of cadmium (II) complex of hydrazone moiety. Research Journal of Applied Biotechnology, 2024; 10(2): 12-23. doi: 10.21608/rjab.2024.312873.1055
Synthesis, characterization and biological activity of cadmium (II) complex of hydrazone moiety
1Genetic Engineering and Biotechnology Research Institute
2Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt
3Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City 32958, Egypt
4Chemistry Department, Faculty of Science, New Valley University, Alkharga 72511, Egypt.
5Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City 32958, Egypt.
Abstract
With the aid of hydrazone moiety, a novel Cd(II) chelate with 2-[(4-methylphenyl)amino]-N'-[(Z)-thiophen-2-ylmethylidene]acetohydrazide (H2L) was created and reported. These novel chemicals' structural makeup was clarified through the utilization of spectroscopic and analytical methods. The chelates were molded with a molar ratio of 1:1 M:L and the formula [Cd(H2L)Cl2]. Cd(II) complex of the biological activity ligand is investigated. Theoretical measurements supported the proposed generic formula for the [Cd(H2L)Cl2] complex. The compound's anticancer and antibacterial properties were evaluated using cisplatin, gentamicin, and ampicillin as standards. It was found that the Cd 2+ complex was more effective against two cancer cell lines and several bacterial strains than it was against ligand. The results showed that the compound's activities were: Cd(II) complex > H2L, with Cd(II) complex exhibiting the maximum activity. By examining the binding between the complex and Penicillin-binding protein PBP, which is primarily thought of as the production of the cell wall through its transglycosylation and transpeptidation, a molecular docking study was carried out to support the microbial inhibition growth.
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