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Dawood, S., Soliman, M., El-Ghamrawy, M., Ismail, H. (2017). BIOMARKERS OF COAGULATION ACTIVATION IN CHILDREN WITH SICKLE CELL DISEASE. Research Journal of Applied Biotechnology, 3(1), 47-52. doi: 10.21608/rjab.2017.57644
Shimaa Dawood; Mohamed A. Soliman; Mona K. El-Ghamrawy; Hisham A. Ismail. "BIOMARKERS OF COAGULATION ACTIVATION IN CHILDREN WITH SICKLE CELL DISEASE". Research Journal of Applied Biotechnology, 3, 1, 2017, 47-52. doi: 10.21608/rjab.2017.57644
Dawood, S., Soliman, M., El-Ghamrawy, M., Ismail, H. (2017). 'BIOMARKERS OF COAGULATION ACTIVATION IN CHILDREN WITH SICKLE CELL DISEASE', Research Journal of Applied Biotechnology, 3(1), pp. 47-52. doi: 10.21608/rjab.2017.57644
Dawood, S., Soliman, M., El-Ghamrawy, M., Ismail, H. BIOMARKERS OF COAGULATION ACTIVATION IN CHILDREN WITH SICKLE CELL DISEASE. Research Journal of Applied Biotechnology, 2017; 3(1): 47-52. doi: 10.21608/rjab.2017.57644

BIOMARKERS OF COAGULATION ACTIVATION IN CHILDREN WITH SICKLE CELL DISEASE

Article 13, Volume 3, Issue 1, June 2017, Page 47-52  XML PDF (346.78 K)
Document Type: Original Article
DOI: 10.21608/rjab.2017.57644
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Authors
Shimaa Dawood email 1; Mohamed A. Soliman2; Mona K. El-Ghamrawy3; Hisham A. Ismail1
1Molecular Diagnostics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat City University, Sadat city, Egypt
2Clinical Pathology Department, Faculty of Medicine, Menoufiyia University, Menoufiya, Egypt.
3Peditric Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt
Abstract
Sickle cell disease (SCD) is a multisystem disease, characterized by its multi-phenotypic diversity although being a disease caused by a single nucleotide substitution.In the present study, we measured biomarkers of coagulation activation in children with SCD. The study was performed on 50 Egyptian children with SCD and 41 age- and sex-matched controls. Complete blood picture (CBC), International normalized ratio (INR)and Partial thromboplastin time (PTT) levels were measured. Thrombin-antithrombin (TAT) plasma levels was estimated by enzyme-linked immunosorbent assay (ELISA). A statically significant increase in all of INR, PTT and TAT plasma levels were detected. We agree with the previous studies that children with SCD exhibit a hypercoagulable state.
Keywords
Sickle cell disease – Hypercoagulability– Thrombin-Antithrombin
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