BIOMARKERS OF COAGULATION ACTIVATION IN CHILDREN WITH SICKLE CELL DISEASE

Document Type : Original Article

Authors

1 Molecular Diagnostics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat City University, Sadat city, Egypt

2 Clinical Pathology Department, Faculty of Medicine, Menoufiyia University, Menoufiya, Egypt.

3 Peditric Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt

Abstract

Sickle cell disease (SCD) is a multisystem disease, characterized by its multi-phenotypic diversity although being a disease caused by a single nucleotide substitution.In the present study, we measured biomarkers of coagulation activation in children with SCD. The study was performed on 50 Egyptian children with SCD and 41 age- and sex-matched controls. Complete blood picture (CBC), International normalized ratio (INR)and Partial thromboplastin time (PTT) levels were measured. Thrombin-antithrombin (TAT) plasma levels was estimated by enzyme-linked immunosorbent assay (ELISA). A statically significant increase in all of INR, PTT and TAT plasma levels were detected. We agree with the previous studies that children with SCD exhibit a hypercoagulable state.

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