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Nasr, M., Ali Deeb, A., Badra, G., El Sayed, I. (2017). INTERLEUKIN-6 (-597G/A) POLYMORPHISM IN EGYPTIAN HEPATITIS C-VIRUS INFECTED PATIENTS. Research Journal of Applied Biotechnology, 3(1), 62-68. doi: 10.21608/rjab.2017.57649
Mohamed Y. Nasr; Ammar S. Ali Deeb; Gamal Badra; Ibrahim H. El Sayed. "INTERLEUKIN-6 (-597G/A) POLYMORPHISM IN EGYPTIAN HEPATITIS C-VIRUS INFECTED PATIENTS". Research Journal of Applied Biotechnology, 3, 1, 2017, 62-68. doi: 10.21608/rjab.2017.57649
Nasr, M., Ali Deeb, A., Badra, G., El Sayed, I. (2017). 'INTERLEUKIN-6 (-597G/A) POLYMORPHISM IN EGYPTIAN HEPATITIS C-VIRUS INFECTED PATIENTS', Research Journal of Applied Biotechnology, 3(1), pp. 62-68. doi: 10.21608/rjab.2017.57649
Nasr, M., Ali Deeb, A., Badra, G., El Sayed, I. INTERLEUKIN-6 (-597G/A) POLYMORPHISM IN EGYPTIAN HEPATITIS C-VIRUS INFECTED PATIENTS. Research Journal of Applied Biotechnology, 2017; 3(1): 62-68. doi: 10.21608/rjab.2017.57649

INTERLEUKIN-6 (-597G/A) POLYMORPHISM IN EGYPTIAN HEPATITIS C-VIRUS INFECTED PATIENTS

Article 15, Volume 3, Issue 1, June 2017, Page 62-68  XML PDF (264.06 K)
Document Type: Original Article
DOI: 10.21608/rjab.2017.57649
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Authors
Mohamed Y. Nasr1; Ammar S. Ali Deeb2; Gamal Badra3; Ibrahim H. El Sayed1
1Molecular Biology department, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat city, Egypt
2Molecular Biology department, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat city, Egypt.
3Internal Medicine Department, National Liver Institute, Menoufia University, Menoufia, Egypt
Abstract
Raised levels of the interleukin (IL-6) have been reported in patients with Hepatitis C Virus (HCV), but it remains debatable whether they are influencedby IL-6 promoter polymorphisms. Therefore, this current study sought to assess whether IL-6(-597G/A) promoter polymorphisms are associated with serum IL-6 levels in HCV patients. Total 102 patients and 103 healthy controls were involved. Sequence specific primers-PCR (SSP-PCR) were used for -597G/A identification . Levels of IL-6 in serum samples were determined by enzyme linked immunosorbent assay (ELISA). The most frequent genotypes were -597G/G in patients and -579G/A in the control group. A significant increase (P<0.001) in -597G/G, in the HCV group against controls, however -597G/A genotype was significantly decreased (P<0.001) in patients. Detection and differentiation of levels of IL-6 were significantly higher (p=0.028) in patients infected with HCV compared with normal group. In serum IL-6 level non significant increase was observed in -597 polymorphism. These results investigate the evaluation of chronic HCV infection with a particular IL-6 polymorphism -597G/A in Egyptian population and there is no effect of polymorphism in IL-6 level.
Keywords
HCV; Polymorphism; IL-6; -597G/A
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