• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Research Journal of Applied Biotechnology
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 11 (2025)
Volume Volume 10 (2024)
Volume Volume 9 (2023)
Volume Volume 8 (2022)
Volume Volume 7 (2021)
Volume Volume 6 (2020)
Volume Volume 5 (2019)
Volume Volume 4 (2018)
Volume Volume 3 (2017)
Volume Volume 2 (2016)
Issue Special issue (1) for the first International Conference of Genetic Engineering and Biotechnology
Issue Special issue (2) for the first International Conference of Genetic Engineering and Biotechnology
Volume Volume 1 (2015)
Hanafy, S., Madi, G., El Hamshary, M., Beshari, W., Mahmoud, H. (2016). VITAMIN D RECEPTOR GENE POLYMORPHISM IN RELATION TO PTH IN CHRONIC KIDNEY DISEASE. Research Journal of Applied Biotechnology, 2(Special issue (2) for the first International Conference of Genetic Engineering and Biotechnology), 43-50. doi: 10.21608/rjab.2016.59833
Shaden M. Hanafy; Gamal E Madi; Manal O El Hamshary; Walid A. Beshari; Heba H. Mahmoud. "VITAMIN D RECEPTOR GENE POLYMORPHISM IN RELATION TO PTH IN CHRONIC KIDNEY DISEASE". Research Journal of Applied Biotechnology, 2, Special issue (2) for the first International Conference of Genetic Engineering and Biotechnology, 2016, 43-50. doi: 10.21608/rjab.2016.59833
Hanafy, S., Madi, G., El Hamshary, M., Beshari, W., Mahmoud, H. (2016). 'VITAMIN D RECEPTOR GENE POLYMORPHISM IN RELATION TO PTH IN CHRONIC KIDNEY DISEASE', Research Journal of Applied Biotechnology, 2(Special issue (2) for the first International Conference of Genetic Engineering and Biotechnology), pp. 43-50. doi: 10.21608/rjab.2016.59833
Hanafy, S., Madi, G., El Hamshary, M., Beshari, W., Mahmoud, H. VITAMIN D RECEPTOR GENE POLYMORPHISM IN RELATION TO PTH IN CHRONIC KIDNEY DISEASE. Research Journal of Applied Biotechnology, 2016; 2(Special issue (2) for the first International Conference of Genetic Engineering and Biotechnology): 43-50. doi: 10.21608/rjab.2016.59833

VITAMIN D RECEPTOR GENE POLYMORPHISM IN RELATION TO PTH IN CHRONIC KIDNEY DISEASE

Article 5, Volume 2, Special issue (2) for the first International Conference of Genetic Engineering and Biotechnology, June 2016, Page 43-50  XML PDF (621.67 K)
Document Type: Original Article
DOI: 10.21608/rjab.2016.59833
View on SCiNiTO View on SCiNiTO
Authors
Shaden M. Hanafy1; Gamal E Madi2; Manal O El Hamshary3; Walid A. Beshari2; Heba H. Mahmoud1
1Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.
2Department of Nephrology, Faculty of Medicine, Ain Shams University, Egypt.
3Molecular Diagnostics and Therapeutics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.
Abstract
Background/Aim: Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate a variety of biological processes, such as bone metabolism, immune response and transcription of several genes involved in chronic kidney disease (CKD).The aim of this work was to investigate the relation between vitamin D receptor genotype and parathyroid hormone (PTH) in predialysis patients and patient on hemodialysis.
Method: We investigated theVDR Taq-I and VDR Bsm-I gene polymorphisms in 46 patients with chronic kidney disease under conservative treatment, 50 patients on hemodialysis and 70 age and sex matched healthy volunteers. This study was performed by restriction fragment length polymorphism (RFLP).
Results: For the Taq-I polymorphism, the T allele is considered as the risk allele. Carrying T allele increases the risk for both chronic kidney disease and renal failure. The risk for CKD increases by 3.3 fold and the risk for renal failure by 8 folds. For the Bsm1 polymorphism, the A allele is considered as the risk allele. Carrying A allele increases the risk for CKD by 3.6 fold and the risk for renal failure by 8 folds.
Conclusion: Bsm1 and Taq1gene polymorphisms of VDR gene were associated with end stage renal disease (ESRD) and with hyperparathyroidism among Egyptian population. Keywords: chronic kidney disease .vitamin D Receptor. Parathyroid hormone.
Keywords
Vitamin D receptor (VDR); Chronic Kidney Disease (CKD); parathyroid hormone (PTH)
Statistics
Article View: 193
PDF Download: 460
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.