Synthesis, Characterization of Cu(I) Complex of Thiosemicarbazone Ligand and Antibacterial Activity of Cu(I) Complex.

Rizk, Nashwa M. H.; Aly, Samar A.; Eldourghamy, Ayman S.; El-Salamony, Magda A.; Hashad, Asmaa S.

doi:10.21608/rjab.2018.106800

Synthesis, Characterization of Cu(I) Complex of Thiosemicarbazone Ligand and Antibacterial Activity of Cu(I) Complex.

Document Type : Original Article

Authors

¹ Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

² Clinical pathology Laboratory Department, Students Hospital, University of Sadat City, Egypt.

10.21608/rjab.2018.106800

Abstract

Novel complex of Cu(I) of ligand 2-(Anilinoacetyl)-N-phenylhydrazine-1-carbothioamide (H2L) has been synthesized and characterized by 1HNMR, IR, elemental analyses, molar conductance, UVvisible spectra, magnetic susceptibility measurements and thermogravimetric analysis (TGA/DTG). The result confirmed that the ligand behaved as neutral bidentate, coordination take place via carbonyl oxygen(C=O) and N(2)H groups. Copper complex is more thermally stable than free ligand. Copper(I) complexes is mononuclear, adopt octahedral geometry. The ligand and complex have been tested for their inhibitory effect on the growth of bacteria against gram-positive (Streptococcus pyogenes) and gram negative (Escherichia coli). The results proved that the copper complex has less potent antibacterial as compared to the ligand.

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