Talaat, R., El-Kelliny, M., El-Akhras, B., Bakry, R., Riad, K., Guirgis, A. (2019). Association of C4125A Polymorphisms of MDR-1 gene with childhood acute lymphoblastic leukaemia in Egyptian. Research Journal of Applied Biotechnology, 5(1), 80-89. doi: 10.21608/rjab.2019.76807
Roba M. Talaat; Medhat Y.K. El-Kelliny; Basima A. El-Akhras; Rania M. Bakry; Khaled F. Riad; Adel A. Guirgis. "Association of C4125A Polymorphisms of MDR-1 gene with childhood acute lymphoblastic leukaemia in Egyptian". Research Journal of Applied Biotechnology, 5, 1, 2019, 80-89. doi: 10.21608/rjab.2019.76807
Talaat, R., El-Kelliny, M., El-Akhras, B., Bakry, R., Riad, K., Guirgis, A. (2019). 'Association of C4125A Polymorphisms of MDR-1 gene with childhood acute lymphoblastic leukaemia in Egyptian', Research Journal of Applied Biotechnology, 5(1), pp. 80-89. doi: 10.21608/rjab.2019.76807
Talaat, R., El-Kelliny, M., El-Akhras, B., Bakry, R., Riad, K., Guirgis, A. Association of C4125A Polymorphisms of MDR-1 gene with childhood acute lymphoblastic leukaemia in Egyptian. Research Journal of Applied Biotechnology, 2019; 5(1): 80-89. doi: 10.21608/rjab.2019.76807
Association of C4125A Polymorphisms of MDR-1 gene with childhood acute lymphoblastic leukaemia in Egyptian
1Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Sadat City, Egypt.
2Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.
3South Egypt Cancer Institute, Assiute University, Egypt.
Abstract
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, though the etiology of the leukemia is poorly understood, both genetic and environmental factors appear to be involved. To investigate the possible role of MDR-1 (C4125A) polymorphism as risk factor for the development of ALL in this study on Egyptian children and to evaluate its prognostic role. Typing of MDR-1 (C4125A) polymorphism was done using RFLP-PCR for 120 patients with ALL and 100 healthy controls. The C allele (100%) and CC genotype (100%) were insignificant in both groups. Also, no relation between clinical data and C4125A genotypes. Thus, MDR-1 (C4125A) SNP may be not risk factor for the development of pediatric ALL in Egyptian patients.
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