Association of C4125A Polymorphisms of MDR-1 gene with childhood acute lymphoblastic leukaemia in Egyptian

Talaat, Roba M.; El-Kelliny, Medhat Y.K.; El-Akhras, Basima A.; Bakry, Rania M.; Riad, Khaled F.; Guirgis, Adel A.

doi:10.21608/rjab.2019.76807

Association of C4125A Polymorphisms of MDR-1 gene with childhood acute lymphoblastic leukaemia in Egyptian

Document Type : Original Article

Authors

¹ Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Sadat City, Egypt.

² Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

³ South Egypt Cancer Institute, Assiute University, Egypt.

10.21608/rjab.2019.76807

Abstract

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, though the etiology of the leukemia is poorly understood, both genetic and environmental factors appear to be involved. To investigate the possible role of MDR-1 (C4125A) polymorphism as risk factor for the development of ALL in this study on Egyptian children and to evaluate its prognostic role. Typing of MDR-1 (C4125A) polymorphism was done using RFLP-PCR for 120 patients with ALL and 100 healthy controls. The C allele (100%) and CC genotype (100%) were insignificant in both groups. Also, no relation between clinical data and C4125A genotypes. Thus, MDR-1 (C4125A) SNP may be not risk factor for the development of pediatric ALL in Egyptian patients.

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